Pathophysiology Of Osteoarthritis Essay Contest



The incidence of joint replacements is considered an indicator of symptomatic end-stage osteoarthritis (OA). We analysed data from two national joint replacement registries in order to investigate whether evidence of a pattern of progression of end-stage hip and knee OA could be found in data from large unselected populations.


We obtained data on 78,634 hip and 122,096 knee arthroplasties from the Australian Orthopaedic Association National Joint Replacement Registry and 19,786 hip and 12,082 knee arthroplasties from the Norwegian Arthroplasty Register. A multi-state model was developed where individuals were followed from their first recorded hip or knee arthroplasty for OA to receiving subsequent hip and/or knee arthroplasties. We used this model to estimate relative hazard rates and probabilities for each registry separately.


The hazard rates of receiving subsequent arthroplasties in non-cognate joints were higher on the contralateral side than on the ipsilateral side to the index arthroplasty, especially if the index was a hip arthroplasty. After 5 years, the estimated probabilities of having received a knee contralateral to the index hip were more than 1.7 times the probabilities of having received a knee ipsilateral to the index hip.


The results indicate that there is an association between the side of the first hip arthroplasty and side of subsequent knee arthroplasties. Further studies are needed to investigate whether increased risk of receiving an arthroplasty in the contralateral knee is related to having a hip arthroplasty and/or preoperative factors such as pain and altered gait associated with hip OA.

Submission deadline: Tuesday 10 April 2018
Meeting date: Tuesday 8 May 2018
Prize: 1st prize = £300, 2nd prize = £200, poster prize = £100 
Open to: Trainee healthcare professionals and undergraduate or graduate research students, working in clinical practice or in basic or clinical research in any area of medicine or science related to the remit of the lipids, metabolism and vascular risk.

Abstracts of no more than 300 words are welcomed for original research, audit, survey, case report or case series undertaken by the applicant in the field of lipids, metabolism & vascular risk.

Submissions will be judged and the top 8 shortlisted submissions will be invited to present their work at Lipids, Metabolism & Vascular Risk Section President's Prize meeting on Tuesday 8 May 2018 Delegates will also be invited to produce an A1 poster to be judged on the day.

At this meeting all presentations will be scored again and 1st, 2nd and 3rd prizes awarded by the President at the end of the meeting.

Candidates should ensure they are available on Tuesday 8 May 2018 for the Lipids, Metabolism & Vascular Risk Section President's Prize meeting.

Successful shortlisted applicants will be notified. 

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